Alpha lipoic acid2/24/2023 ![]() ![]() Long-term use of R-ALA, which has increased bioavailability, produced modest weight loss in overweight/obese adults without significant reductions in triglyceride levels (47). In other preliminary studies, ALA induced mild weight loss and waist circumference reduction in overweight or obese subjects (23). Meta-analyses also suggest ALA supplementation may reduce inflammatory mediators such as CRP, IL-6, TNF-α, and improve some glucose and lipid parameters (30) (31) (32) (33) (34), but confirming studies are needed. In women with gestational diabetes, oral ALA may improve liver function and glucose metabolism (29). Data from a double-blind RCT suggest short-term ALA supplementation can be beneficial for idiopathic pain without altering glycemia in patients with normal levels (45), but another trial did not find it helpful for fibromyalgia (46). Studies of intravenous and oral forms suggest improved insulin sensitivity, vasodilation, and neuropathy symptoms in diabetic patients (5) (6) (7) (21) (28), although earlier studies to determine its role in reversing neuropathies (8) (9) and liver disease (10) (11) produced mixed results. Preliminary data suggest long-term supplementation may help preserve walking ability in patients with secondary progressive multiple sclerosis, especially those with less disability at baseline (27). Studies on ALA in humans have been conducted across various populations. Preclinical studies show that ALA plays a crucial role in energy production, and exerts antioxidant and apoptotic effects (1) (2) (3). It is marketed as a dietary supplement for this reason, and is also used as adjuvant therapy for neuropathy and to improve glycemic control. ALA is sometimes referred to as a “universal antioxidant” because it is both water- and fat-soluble and can neutralize free radicals (26). It can be obtained from a variety of foods in the diet. In using this website you agree that neither Memorial Sloan Kettering nor any other party is or will be liable or otherwise responsible for any decision made or any action taken or any action not taken due to your use of any information presented at this website.Īlpha lipoic acid (ALA) is an endogenous cofactor found in cells. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. Use of this Web site does not create an expressed or implied physician-patient relationship. Statements made about products have not been evaluated by the Food and Drug Administration. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. Memorial Sloan Kettering does not assume any risk whatsoever for your use of this website or the information contained herein. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. Users of this Web site should not rely on information provided on this Web site for their own health problems. ![]() This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. This Web site - Information About Herbs, Botanicals and Other Products - is for general health information only. ![]()
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